The term differentiated thyroid cancer encompasses papillary cancer and follicular cancer. Papillary cancer (that includes mixed papillary-follicular cancer) accounts for the majority of thyroid cancers, that is, approximately 75% of cases, whereas follicular cancer accounts for only about 10% of cases. It is important to separate patients with differentiated cancers into those with good to excellent prognoses vs those with poorer prognoses. In general, patients with a low risk for recurrence or death and a good prognosis are those with small tumors (</=2 cm), females, and those with neither local invasiveness or distant metastases.[7] Cervical nodal disease as an independent variable may be associated with higher recurrence rates, and bilateral cervical nodal or mediastinal involvement may impart a poorer overall prognosis.[8] Management of such patients is done best by physicians with a particular interest in diseases of the thyroid gland, usually endocrinologists, who are especially knowledgeable about the various modalities of therapy and their appropriate use in individual patients.